ARK NUOVA
Clinical Research Made Easier
In -Vitro Research Services
Explore our cutting-edge lab experiments and innovative research services aimed at advancing medical science.
Cell Culture Assays
Cell Culture Assays: Use isolated cells (e.g., immortalized or primary cell lines) in a dish.
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Cell Viability/Cytotoxicity Assays (e.g., MTT Assay): Measures how many cells survive after exposure to a substance (like a potential drug or toxin).
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Cell Proliferation/Migration Assays: Studies cell growth and movement, often relevant in cancer research.
Biochemical Assays
Biochemical Assays: Focus on the activity of isolated molecules.
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Receptor Binding Assays: Measures how strongly a compound binds to a specific cellular receptor.
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Enzyme Assays: Measures the rate at which an enzyme processes a substrate.
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Genetic Toxicology Assays
Genetic Toxicology Assays: Evaluates the potential of a substance to damage genetic material.
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Ames Test: A bacterial assay to test for gene mutations.
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Micronucleus Test: Used to evaluate chromosomal damage.
3D Cell Culture and Organ-on-a-Chip
3D Cell Culture and Organ-on-a-Chip: Advanced in vitro models that better mimic the complex environment of an organ or tissue.
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Spheroids/Organoids: Three-dimensional cell aggregates that resemble miniature organs or tumors, used to study disease or test drugs.
In -Vivo Research Services
These are mandatory tests on animals (e.g., mice, rats, dogs) during the drug development process to determine a drug candidate's safety and efficacy before human trials.
Pharmacokinetics (PK) and Toxicokinetics (TK) Studies
Safety and Toxicology Studies
Efficacy Studies
PK/TK
Absorption, Distribution, Metabolism, and Excretion (ADME) - Determines how the body handles the drug: how it's absorbed into the bloodstream, where it distributes, how it's metabolized (broken down), and how it's excreted (eliminated).
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Bioavailability Studies - Measures the proportion of a drug that enters the circulation and is able to have an active effect.
Toxicity
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Acute Toxicity Studies - Assesses the immediate, short-term effects of a single, high dose; often to determine the Maximum Tolerated Dose (MTD).
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Repeat-Dose (Sub-chronic/Chronic) Toxicity - Assesses the effects of repeated administration over weeks or months, looking for cumulative toxicity.
Carcinogenicity Studies - Long-term study (up to two years) to assess a substance's potential to cause cancer.
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Specialized Toxicology
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Developmental and Reproductive Toxicology (DART) - Evaluates adverse effects on fertility, gestation, embryo-fetal development, and offspring.
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Safety Pharmacology (ICH Core Battery) - Specifically examines the effects of the drug on vital functions (cardiovascular, respiratory, and central nervous systems).
Efficacy
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Therapeutic Efficacy Assessment - Administering the compound to an animal model of a specific human disease (e.g., a mouse with induced cancer or diabetes) to see if the treatment works.
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Dose-Response Studies - Determines the relationship between the dose of a drug and the magnitude of the resulting therapeutic effect.
Clinical Trial Management
Explore our cutting-edge lab experiments and innovative research services aimed at advancing medical science and improving patient care.
End to End Management for Phase 1-4
Participate in our groundbreaking clinical trials to contribute to the development of new treatments and therapies for various medical conditions.
Site Management
Join us in our genetic studies to unravel the mysteries of inherited diseases and pave the way for personalized medicine approaches.
Consultation Services
Benefit from our expert consultation services tailored to guide you through research protocols, data analysis, and project management.